White matter microstructure and cognitive outcomes in relation to neonatal inflammation in 6-year-old children born preterm.

ABSTRACT:

Background

Cognitive outcomes in preterm (PT) children have been associated with microstructural properties of white matter. PT children who experienced neonatal inflammatory conditions have poorer cognitive outcomes than those who did not. The goal of this study was to contrast white matter microstructure and cognitive outcomes after preterm birth in relation to the presence or absence of severe inflammatory conditions in the neonatal period.

Methods

PT children (n = 35), born at gestational age 22-32 weeks, were classified as either PT+ (n = 12) based on a neonatal history of inflammatory conditions, including bronchopulmonary dysplasia, necrotizing enterocolitis or culture positive sepsis, or PT- (n = 23) based on the absence of the three inflammatory conditions. Full ter

SUBMITTER: Dubner SE 

PROVIDER: S-EPMC6603335 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature