Accelerated podocyte detachment early after kidney transplantation is related to long-term allograft loss of function.

ABSTRACT:

Background

Kidney allograft half-life has not improved despite excellent short-term survival. Recent long-term surveillance biopsy studies identify accumulating glomerulosclerosis (GS) to be associated with late allograft loss. While podocyte depletion is well known to drive proteinuria and GS in animal models and human glomerular diseases, its role in renal allograft loss of function is generally not recognized.

Methods

To address these questions, we collected urine from 125 kidney allograft recipients in the first posttransplant year for urine pellet messenger RNA (mRNA) and protein analysis, with a median follow up of 4.5 years.

Results

Using multivariable linear models adjusted for proteinuria, transplant, recipient and donor factors, we observed that the average

SUBMITTER: Naik AS 

PROVIDER: S-EPMC6603364 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature