Identification of the primate-specific gene BTN3A2 as an additional schizophrenia risk gene in the MHC loci.

ABSTRACT:

Background

Schizophrenia is a complex mental disorder resulting in poor life quality and high social and economic burden. Despite the fact that genome-wide association studies (GWASs) have successfully identified a number of risk loci for schizophrenia, identifying the causal genes at the risk loci and elucidating their roles in disease pathogenesis remain major challenges.

Methods

The summary data-based Mendelian randomization analysis (SMR) was used to integrate a large-scale GWAS of schizophrenia with brain expression quantitative trait loci (eQTL) data and brain methylation expression quantitative trait loci (meQTL) data, to identify novel risk gene(s) for schizophrenia. We then analyzed the mRNA expression and methylation statuses of the gene hit BTN3A2 during the early

SUBMITTER: Wu Y 

PROVIDER: S-EPMC6603853 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature