Thrombocyte Inhibition Restores Protective Immunity to Mycobacterial Infection in Zebrafish.

ABSTRACT:

Background

Infection-induced thrombocytosis is a clinically important complication of tuberculosis infection. Recent studies have highlighted the utility of aspirin as a host-directed therapy modulating the inflammatory response to infection but have not investigated the possibility that the effect of aspirin is related to an antiplatelet mode of action.

Methods

In this study, we utilize the zebrafish-Mycobacterium marinum model to show mycobacteria drive host hemostasis through the formation of granulomas. Treatment of infected zebrafish with aspirin markedly reduced mycobacterial burden. This effect is reproduced by treatment with platelet-specific glycoprotein IIb/IIIa inhibitors demonstrating a detrimental role for infection-induced thrombocyte activation.

Results

SUBMITTER: Hortle E 

PROVIDER: S-EPMC6603966 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature