Impact of Pretransplant Donor BK Viruria in Kidney Transplant Recipients.

ABSTRACT:

Background

BK virus (BKV) is a significant cause of nephropathy in kidney transplantation. The goal of this study was to characterize the course and source of BKV in kidney transplant recipients.

Methods

We prospectively collected pretransplant plasma and urine samples from living and deceased kidney donors and performed BKV polymerase chain reaction (PCR) and immunoglobulin G (IgG) testing on pretransplant and serially collected posttransplant samples in kidney transplant recipients.

Results

Among deceased donors, 8.1% (17/208) had detectable BKV DNA in urine prior to organ procurement. BK viruria was observed in 15.4% (6/39) of living donors and 8.5% (4/47) of deceased donors of recipients at our institution (P = .50). BKV VP1 sequencing revealed identical virus bet

SUBMITTER: Tan SK 

PROVIDER: S-EPMC6603974 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature