Progressive Cortical Thinning in Patients With Focal Epilepsy.

ABSTRACT:

Importance

It is controversial whether epilepsy is a static or progressive disease. Evidence of progressive gray matter loss in epilepsy would support early diagnosis, rapid treatment, and early referral for surgical interventions.

Objective

To demonstrate progressive cortical thinning in patients with focal epilepsy distinct from cortical thinning associated with normal aging.

Design, setting, and participants

A case-control neuroimaging study was conducted from August 3, 2004, to January 26, 2016, among 190 patients with focal epilepsy at a tertiary epilepsy referral center (epilepsy data) and 3 independent comparison cohorts matched for age and sex (healthy volunteer data; n = 141).

Exposures

Two or more high-resolution T1-weighted magnetic resonance imaging

SUBMITTER: Galovic M 

PROVIDER: S-EPMC6604082 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature