Genetic Variants Associated With Corneal Biomechanical Properties and Potentially Conferring Susceptibility to Keratoconus in a Genome-Wide Association Study.

ABSTRACT:

Importance

Keratoconus is an important cause of visual loss in young adults, but little is known about its genetic causes. Understanding the genetic determinants of corneal biomechanical factors may in turn teach us about keratoconus etiology.

Objectives

To identify genetic associations with corneal biomechanical properties and to examine whether these genetic variants are associated with keratoconus.

Design, setting, and participants

A stage 1 discovery and replication genome-wide association study (GWAS) of corneal biomechanical properties was performed in 2 cross-sectional populations (6645 participants from the European Prospective Investigation into Cancer and Nutrition [EPIC]-Norfolk Eye Study and 2384 participants from the TwinsUK study). In stage 2, the associ

SUBMITTER: Khawaja AP 

PROVIDER: S-EPMC6604088 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature