Association of Radioactive Iodine Treatment With Cancer Mortality in Patients With Hyperthyroidism.

ABSTRACT:

Importance

Radioactive iodine (RAI) has been used extensively to treat hyperthyroidism since the 1940s. Although widely considered a safe and effective therapy, RAI has been associated with elevated risks of total and site-specific cancer death among patients with hyperthyroidism.

Objective

To determine whether greater organ- or tissue-absorbed doses from RAI treatment are associated with overall and site-specific cancer mortality in patients with hyperthyroidism.

Design, setting, and participants

This cohort study is a 24-year extension of the multicenter Cooperative Thyrotoxicosis Therapy Follow-up Study, which has followed up US and UK patients diagnosed and treated for hyperthyroidism for nearly 7 decades, beginning in 1946. Patients were traced using records from

SUBMITTER: Kitahara CM 

PROVIDER: S-EPMC6604114 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature