Association of Weight Loss Interventions With Changes in Biomarkers of Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis.

ABSTRACT:

Importance

Nonalcoholic fatty liver disease (NAFLD) affects about 25% of adults worldwide and is associated with obesity. Weight loss may improve biomarkers of liver disease, but its implications have not been systematically reviewed and quantified.

Objective

To estimate the association of weight loss interventions with biomarkers of liver disease in NAFLD.

Data sources

MEDLINE, Embase, PsycINFO, CINAHL, Cochrane, and Web of Science databases along with 3 trial registries were searched from inception through January 2019.

Study selection

Randomized clinical trials of people with NAFLD were included if they compared any intervention aiming to reduce weight (behavioral weight loss programs [BWLPs], pharmacotherapy, and surgical procedures) with no or lower-intens

SUBMITTER: Koutoukidis DA 

PROVIDER: S-EPMC6604126 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature