A technique for approximating transition rates from published survival analyses.

ABSTRACT:

Background

Quality-adjusted-life-years (QALYs) are used to concurrently quantify morbidity and mortality within a single parameter. For this reason, QALYs can facilitate the discussion of risks and benefits during patient counseling regarding treatment options. QALYs are often calculated using partitioned-survival modelling. Alternatively, QALYs can be calculated using more flexible and informative state-transition models populated with transition rates estimated using multistate modelling (MSM) techniques. Unfortunately the latter approach is considered not possible when only progression-free survival (PFS) and overall survival (OS) analyses are reported.

Methods

We have developed a method that can be used to estimate approximate transition rates from published PFS a

SUBMITTER: Pahuta MA 

PROVIDER: S-EPMC6604134 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature