Sex differences in gray matter volume: how many and how large are they really?

ABSTRACT: BACKGROUND:Studies assessing volumetric sex differences have provided contradictory results. Total intracranial volume (TIV) is a major confounding factor when estimating local volumes of interest (VOIs). We investigated how the number, size, and direction of sex differences in gray matter volume (GMv) vary depending on how TIV variation is statistically handled. METHODS:Sex differences in the GMv of 116 VOIs were assessed in 356 participants (171 females) without correcting for TIV variation or after adjusting the data with 5 different methods (VBM8 non-linear-only modulation, proportions, power-corrected-proportions, covariation, and the residuals method). The outcomes obtained with these procedures were compared to each other and to those obtained in three criterial subsamples, one comp

SUBMITTER: Sanchis-Segura C 

PROVIDER: S-EPMC6604149 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature