Proteomic profiling of plasma biomarkers in acute ischemic stroke due to large vessel occlusion.

ABSTRACT:

Background

Acute ischemic stroke (AIS) due to large vessel occlusion (LVO) is a devastating cerebrovascular disorder, which could benefit from collateral circulation. Proteins associated with acute LVO pathogenesis and endothelial function may appear in blood samples of AIS patients due to LVO, thus permitting development of blood-based biomarkers for its diagnosis and prognosis.

Methods

This study is a single-center, retrospective, observational case-control trial. Consecutive patients who presented at the Department of Neurology of Tongji Hospital were recruited from July 2016 to April 2018. In the discovery phase, a proteomic approach with iTRAQ-based LC-MS/MS was used to investigate the altered proteomic pattern in plasma from patients with AIS due to LVO. In the validat

SUBMITTER: Qin C 

PROVIDER: S-EPMC6604304 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature