Early-life determinants of hypoxia-inducible factor 3A gene (HIF3A) methylation: a birth cohort study.

ABSTRACT:

Background

Methylation of the hypoxia-inducible factor 3α gene (HIF3A) has been linked to pregnancy exposures, infant adiposity and later BMI. Genetic variation influences HIF3A methylation levels and may modify these relationships. However, data in very early life are limited, particularly in association with adverse pregnancy outcomes. We investigated the relationship between maternal and gestational factors, infant anthropometry, genetic variation and HIF3A DNA methylation in the Barwon Infant Study, a population-based birth cohort. Methylation of two previously studied regions of HIF3A were tested in the cord blood mononuclear cells of 938 infants.

Results

No compelling evidence was found of an association between birth weight, adiposity or maternal gestational diabetes

SUBMITTER: Mansell T 

PROVIDER: S-EPMC6604333 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature