In-depth characterization of congenital Zika syndrome in immunocompetent mice: Antibody-dependent enhancement and an antiviral peptide therapy.

ABSTRACT:

Background

Zika virus (ZIKV) infection during pregnancy may cause major congenital defects, including microcephaly, ocular, articular and muscle abnormalities, which are collectively defined as Congenital Zika Syndrome. Here, we performed an in-depth characterization of the effects of congenital ZIKV infection (CZI) in immunocompetent mice.

Methods

Pregnant dams were inoculated with ZIKV on embryonic day 5.5 in the presence or absence of a sub-neutralizing dose of a pan-flavivirus monoclonal antibody (4G2) to evaluate the potential role of antibody-dependent enhancement phenomenon (ADE) during short and long outcomes of CZI.

Findings

ZIKV infection induced maternal immune activation (MIA), which was associated with occurrence of foetal abnormalities and death. Therape

SUBMITTER: Camargos VN 

PROVIDER: S-EPMC6604363 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature