Three kinds of corneal host cells contribute differently to corneal neovascularization.

ABSTRACT:

Background

Corneal neovascularization (angiogenesis and lymphangiogenesis) compromises corneal transparency and transplant survival, however, the molecular mechanisms of corneal host epithelial and stromal cells in neovascularization have not yet been fully elucidated. Furthermore, the contribution and mechanism of corneal host endothelial cells involved in neovascularization are largely unexplored.

Methods

Liquid chromatography-mass spectrometry, immunoblotting, and ELISA were used to screen and identify potential neovascularization-related factors in human full-thickness vascularized corneal tissues. Lipopolysaccharide was used to induce inflammation in three kinds of corneal host cells in vitro, including corneal epithelial, stromal, and endothelial cells. Fungus was used

SUBMITTER: Yu H 

PROVIDER: S-EPMC6604366 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature