Age associated non-linear regulation of redox homeostasis in the anucleate platelet: Implications for CVD risk patients.

ABSTRACT:

Background

Aging is a complex physiological phenomenon, intricately associated with cardiovascular pathologies, where platelets play a central pathophysiological role. Although antiplatelets are commonly employed to prevent and treat major adverse cardiovascular events, aging associated intraplatelet changes remain largely unexplored.

Methods

Platelets were studied in high cardiovascular risk patients (aged 40-100 years) comparing them to younger healthy subjects. This was followed by cross sectional and longitudinal mice studies. Flow cytometry, biochemical and molecular assays were used to study platelets comprehensively.

Findings

CVD Patients were categorized in the age groups 40-59, 60-79, and 80-100 years. Progressive decline in platelet health was observed in th

SUBMITTER: Jain K 

PROVIDER: S-EPMC6604369 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature