Associations between cardiorespiratory fitness and weight loss in patients with severe obesity undergoing an intensive lifestyle intervention program: retrospective cohort study.

ABSTRACT: BACKGROUND:To assess the association between cardiorespiratory fitness (CRF) and weight changes in treatment seeking patients with severe obesity who underwent a 1-year intensive lifestyle intervention (ILI) program. METHODS:Retrospective cohort study conducted at a tertiary care outpatient rehabilitation center from November 1, 2013 through January 1, 2017. CRF was measured as maximal oxygen consumption during a maximal oxygen uptake (VO2max) test on a treadmill or bicycle at baseline and after 3?months. RESULTS:A total of 180 patients had a baseline mean (SD) BMI 41.1 (4.8) kg/m2 and CRF of 79.4 (14.9) mL·kg-0.75·min-?1. Patients with a baseline CRF above median achieved a greater 3-month and 1-year weight loss compared with patients with CRF below median; mean (95% CI) 2.5?kg (1.3, 3.8) and 4.0?kg (0.8, 7.2), respectively. In addition, patients with 3-month changes of CRF above median had 4.0?kg (0.9, 7.1) greater weight loss at 1-year follow-up than those below median. CONCLUSIONS:Among patients with severe obesity who underwent a 1-year ILI program, higher baseline CRF was associated with significantly larger weight loss after 3?months and 1?year. In addition, those with higher initial 3-month CRF changes had greater weight loss at 1?year. TRIAL REGISTRATION:Retrospectively registered in Regional Committees for Medical and Health Research Ethics (REC) south east September 22, 2016 (2016/1414) and clinicaltials.gov August 13, 2018 (identifier: NCT03593798 ).

SUBMITTER: Berge J 

PROVIDER: S-EPMC6604389 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature