Unique microglia expression profile in developing white matter.

ABSTRACT:

Objective

Recently we demonstrated that amoeboid microglia in white matter regions are essential for proper oligodendrocyte homeostasis and myelinogenesis in the first postnatal week. Amoeboid microglia in the mouse corpus callosum change their activation profile within few days after postnatal day (P)7 with microglia of the cerebellum showing similar features. Here we expanded our previous transcriptional analysis and performed detailed bulk RNA sequencing of microglia from corpus callosum, cortex and cerebellum at P7, P10 and P42. The goal of this study was to identify a specific gene profile for both, white matter and grey matter microglia during development.

Results

Microglia in white matter regions display unique characteristics in the first postnatal week of murine lif

SUBMITTER: Staszewski O 

PROVIDER: S-EPMC6604453 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature