Tissue engineering in pediatric urology - a critical appraisal.

ABSTRACT: Tissue engineering is defined as the combination of biomaterials and bioengineering principles together with cell transplantation or directed growth of host cells to develop a biological replacement tissue or organ that can be a substitute for normal tissue both in structure and function. Despite early promising preclinical studies, clinical translation of tissue engineering in pediatric urology into humans has been unsuccessful both for cell-seeded and acellular scaffolds. This can be ascribed to various factors, including the use of only non-diseased models that inaccurately describe the structural and functional modifications of diseased tissue. The paper addresses potential future strategies to overcome the limitations experienced in clinical applications so far. This includes the use

SUBMITTER: Schafer FM 

PROVIDER: S-EPMC6604568 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature