¹⁸F-Branched-Chain Amino Acids: Structure-Activity Relationships and PET Imaging Potential.

ABSTRACT: The large, neutral L-type amino acid transporters (LAT1-LAT4) are sodium-independent transporters that are widely distributed throughout the body. LAT expression levels are increased in many types of cancer, and their expression increases as cancers progress, leading to high expression levels in high-grade tumors and metastases. Because of the key role and overexpression of LAT in many types of cancer, radiolabeled LAT substrates are promising candidates for nuclear imaging of malignancies that are not well revealed by conventional radiotracers. The goal of this study was to examine the structure-activity relationships of a series of ¹⁸F-labeled amino acids that were predicted to be substrates of the LAT transport system. Methods: Using a photocatalytic radical fluorinati

SUBMITTER: Nodwell MB 

PROVIDER: S-EPMC6604688 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature