Detection Rate of ¹⁸F-Choline PET/CT and ⁶⁸Ga-PSMA-HBED-CC PET/CT for Prostate Cancer Lymph Node Metastases with Direct Link from PET to Histopathology: Dependence on the Size of Tumor Deposits in Lymph Nodes.

ABSTRACT: Accurate detection of prostate cancer lymph node metastases (LNM) through PET/CT before lymphadenectomy is crucial for successful therapy. PET/CT with choline derivatives used to be the standard tool for imaging metastases, whereas ⁶⁸Ga-PSMA (prostate-specific membrane antigen) PET/CT was introduced recently. Both PET techniques were investigated with respect to what extent the detection rate of LNM depends on the size of tumor deposits (TDs) within LNM. Methods: Documenting the switch from the use of ¹⁸F-choline to ⁶⁸Ga-PSMA in 2014, we used 2 patient cohorts undergoing a template lymphadenectomy because of a PET/CT indicating LNM. Forty-four and 40 patients underwent PET/CT with ¹⁸F-choline or ⁶⁸Ga-PSMA ligand, respectively. I

SUBMITTER: Jilg CA 

PROVIDER: S-EPMC6604697 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature