The Genotype Frequency of CYP2C19 Enzyme after Liver Transplantation.

ABSTRACT:

Background

Liver transplant recipients are treated with various drugs, the metabolism of which is dependent on the cytochrome P450 polymorphic genotype.

Objective

To identify the polymorphic variety of CYP2C19 genotype in liver allograft before and after transplantation.

Methods

The study was conducted on 88 liver recipients. The CYP2C19 genotypes in donors and recipients were the same in 32 and different in 56 recipients. Extracted genomic DNA from the leukocytes and liver graft tissues were analyzed by TaqMan SNP genotyping assay. The distributions of homozygote, heterozygote, poor and ultra-rapid metabolizers' genotypes were investigated in both groups.

Results

The distributions of CYP2C19 genotypes before transplantation in the blood and liver graft were wi

SUBMITTER: Badiee P 

PROVIDER: S-EPMC6604758 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature