Penaeus monodon IKKs Participate in Regulation of Cytokine-Like System and Antiviral Responses of Innate Immune System.

ABSTRACT: The IKK-NF-κB signaling cascade is one of the crucial responsive mechanisms in inflammatory and immune responses. The key kinase proteins called inhibitor of kappa B kinases (IKKs) serve as the core elements involved in cascade activation. Here, the complete ORFs of IKK homologs, PmIKKβ, PmIKKε1, and PmIKKε2, from the black tiger shrimp Penaeus monodon were identified and characterized for their functions in shrimp antiviral responses. The PmIKK transcripts were widely expressed in various examined tissues and the PmIKKε protein was detected in all three types of shrimp hemocytes. Only the PmIKKε1 and PmIKKε2 were responsive to white spot syndrome virus (WSSV), yellow head

SUBMITTER: Nhnhkorn Z 

PROVIDER: S-EPMC6604761 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature