TRIM33 deficiency in monocytes and macrophages impairs resolution of colonic inflammation.

ABSTRACT:

Background

Mature myeloid cells play a crucial role in Crohn's disease (CD) but the molecular players that regulate their functions in CD are not fully characterized. We and others have shown that TRIM33 is involved in the innate immune response and in the inflammatory response but TRIM33 role in intestinal inflammation is not known. In this study, we investigated the role of TRIM33 in myeloid cells during dextran sulfate sodium (DSS)-induced colitis.

Methods

We study the role of TRIM33 during DSS-induced colitis which mimics intestinal inflammation using mice deleted for Trim33 only in mature myeloid cells (Trim33^-/- mice) FINDINGS: We first show that Trim33 mRNA level is decreased in CD patient's blood monocytes suggesting a role of TRIM33 in CD. Using Trim33

SUBMITTER: Petit V 

PROVIDER: S-EPMC6604767 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature