Ca²⁺ and CACNA1H mediate targeted suppression of breast cancer brain metastasis by AM RF EMF.

ABSTRACT:

Background

Brain metastases are a major cause of death in patients with metastatic breast cancer. While surgical resection and radiation therapy are effective treatment modalities, the majority of patients will succumb from disease progression. We have developed a novel therapy for brain metastases that delivers athermal radiofrequency electromagnetic fields that are amplitude-modulated at breast cancer specific frequencies (BCF).

Methods

27.12 MHz amplitude-modulated BCF were administered to a patient with a breast cancer brain metastasis by placing a spoon-shaped antenna on the anterior part of the tongue for three one-hour treatments every day. In preclinical models, a BCF dose, equivalent to that delivered to the patient's brain, was administered to animals implanted wit

SUBMITTER: Sharma S 

PROVIDER: S-EPMC6604768 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature