Trends in antiretroviral therapy prescription, durability and modification: new drugs, more changes, but less failure.

ABSTRACT:

Objective

To evaluate the real world durability of contemporary ART for treatment-naïve people living with HIV (PLWH).

Design

A retrospective follow-up study in a multisite cohort.

Methods

This study of the CNICS (CFAR Network of Integrated Clinical Systems) cohort integrates data from eight Center for AIDS Research (CFARs). PLWH initiating ART between 2007 and 2014 were included. Durability was defined as time from the initiation until discontinuation/modification using Kaplan-Meier survival curves. Cox Proportional Hazards measured associations with various sociodemographic and clinical characteristics.

Results

Among 5373 PLWH, the initial regimen was modified in 2285 (43%) patients. Efavirenz/emtricitabine/tenofovir (n = 2173, 40%) was the most commonly pres

SUBMITTER: Eaton EF 

PROVIDER: S-EPMC6604808 | biostudies-literature | 2018 Jan

REPOSITORIES: biostudies-literature