Cholinergic Regulation of hnRNPA2/B1 Translation by M1 Muscarinic Receptors.

ABSTRACT:

Unlabelled

Cholinergic vulnerability, characterized by loss of acetylcholine (ACh), is one of the hallmarks of Alzheimer's disease (AD). Previous work has suggested that decreased ACh activity in AD may contribute to pathological changes through global alterations in alternative splicing. This occurs, at least partially, via the regulation of the expression of a critical protein family in RNA processing, heterogeneous nuclear ribonucleoprotein (hnRNP) A/B proteins. These proteins regulate several steps of RNA metabolism, including alternative splicing, RNA trafficking, miRNA export, and gene expression, providing multilevel surveillance in RNA functions. To investigate the mechanism by which cholinergic tone regulates hnRNPA2/B1 expression, we used a combination of genetic mouse mo

SUBMITTER: Kolisnyk B 

PROVIDER: S-EPMC6604881 | biostudies-literature | 2016 Jun

REPOSITORIES: biostudies-literature