Allergic Inflammation Leads to Neuropathic Pain via Glial Cell Activation.

ABSTRACT: Allergic and atopic disorders have increased over the past few decades and have been associated with neuropsychiatric conditions, such as autism spectrum disorder and asthmatic amyotrophy. Myelitis presenting with neuropathic pain can occur in patients with atopic disorder; however, the relationship between allergic inflammation and neuropathic pain, and the underlying mechanism, remains to be established. We studied whether allergic inflammation affects the spinal nociceptive system. We found that mice with asthma, atopic dermatitis, or atopic diathesis had widespread and significantly more activated microglia and astroglia in the spinal cord than those without atopy, and displayed tactile allodynia. Microarray analysis of isolated microglia revealed a dysregulated phenotype showing upreg

SUBMITTER: Yamasaki R 

PROVIDER: S-EPMC6604914 | biostudies-literature | 2016 Nov

REPOSITORIES: biostudies-literature