Intrinsic role of coagulase negative staphylococci norA-like efflux system in fluoroquinolones resistance.

ABSTRACT: NorA is a Staphylococcus aureus multidrug transporter that exports structurally distinct compounds including fluoroquinolones. In this study norA-like genes of Staphylococcus epidermidis (norA _SEP) and Staphylococcus haemolyticus (norA _SHAE) were identified and sequenced. The nucleotide identity of norA _SEP and norA _SHAE with norA was 75.3 and 74.1%, respectively, and the amino acid identity 87.7 and 86%, respectively. Inactivation of norA _SEP increased the ciprofloxacin susceptibility of E. coli DH5α carrying the pB SK 198 norA _SEP EZ cat norA _SEP plasmid.

SUBMITTER: Marco L 

PROVIDER: S-EPMC6604952 | biostudies-literature | 2017

REPOSITORIES: biostudies-literature