Agonist-dependent modulation of cell surface expression of the cold receptor TRPM8.

ABSTRACT: The spatial and temporal distribution of receptors constitutes an important mechanism for controlling the magnitude of cellular responses. Several members of the transient receptor potential (TRP) ion channel family can regulate their function by modulating their expression at the plasma membrane (PM) through rapid vesicular translocation and fusion. The mechanisms underlying this regulation are not completely understood, and the contribution of vesicular trafficking to physiological function is unknown. TRPM8 receptors are expressed in mammalian peripheral sensory neurons and are essential for the detection of cold temperatures. Previously, we showed that TRPM8-containing vesicles are segregated into three main pools, immobile at the PM, simple diffusive and corralled-hopping. Here, we sh

SUBMITTER: Toro CA 

PROVIDER: S-EPMC6605369 | biostudies-literature | 2015 Jan

REPOSITORIES: biostudies-literature