Rapid resensitization of ASIC2a is conferred by three amino acid residues in the N terminus.

ABSTRACT: Acid-sensing ion channels (ASICs), sensory molecules that continuously monitor the concentration of extracellular protons and initiate diverse intracellular responses through an influx of cations, are assembled from six subtypes that can differentially combine to form various trimeric channel complexes and elicit unique electrophysiological responses. For instance, homomeric ASIC1a channels have been shown to exhibit prolonged desensitization, and acid-evoked currents become smaller when the channels are repeatedly activated by extracellular protons, whereas homomeric or heteromeric ASIC2a channels continue to respond to repetitive acidic stimuli without exhibiting such desensitization. Although previous studies have provided evidence that both the desensitization of ASIC1a and rapid resen

SUBMITTER: Lee JS 

PROVIDER: S-EPMC6605689 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature