TCF-1 limits the formation of Tc17 cells via repression of the MAF-RORγt axis.

ABSTRACT: Interleukin (IL)-17-producing CD8⁺ T (Tc17) cells have emerged as key players in host-microbiota interactions, infection, and cancer. The factors that drive their development, in contrast to interferon (IFN)-γ-producing effector CD8⁺ T cells, are not clear. Here we demonstrate that the transcription factor TCF-1 (Tcf7) regulates CD8⁺ T cell fate decisions in double-positive (DP) thymocytes through the sequential suppression of MAF and RORγt, in parallel with TCF-1-driven modulation of chromatin state. Ablation of TCF-1 resulted in enhanced Tc17 cell development and exposed a gene set signature to drive tissue repair and lipid metabolism, which was distinct from other CD8⁺ T cell subsets. IL-17-producing CD8⁺ T cells isolated fro

SUBMITTER: Mielke LA 

PROVIDER: S-EPMC6605755 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature