Effect of alcohol skin cleansing on vaccination-associated infections and local skin reactions: a randomized controlled trial.

ABSTRACT:

Objectives

Recommendations regarding the need to use alcohol prior to vaccine injections are inconsistent and based on low-level evidence. The objective was to assess the effectiveness of alcohol in reducing local skin reactions and infection post-vaccination.

Methods

Randomized controlled trial in a pediatric clinic. A research assistant cleansed the skin with alcohol at (swab group) or adjacent to (control group) the pre-defined injection site(s). Clinicians, parents and children were blinded to group allocation. Parents reported local skin reactions using paper diaries for 15 days post-vaccination (Day 0-14). Telephone interviews were conducted Day 1, 5, and 14. The Brighton Collaboration criteria were used to diagnose cellulitis and infectious abscess Day 5 and afterward

SUBMITTER: Wong H 

PROVIDER: S-EPMC6605859 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature