Ontology highlight
ABSTRACT:
SUBMITTER: Hardy H
PROVIDER: S-EPMC6606025 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
eLife 20190604
Epithelial fusion underlies many vital organogenic processes during embryogenesis. Disruptions to these cause a significant number of human birth defects, including ocular coloboma. We provide robust spatial-temporal staging and unique anatomical detail of optic fissure closure (OFC) in the embryonic chick, including evidence for roles of apoptosis and epithelial remodelling. We performed complementary transcriptomic profiling and show that <i>Netrin</i>-1 (<i>NTN1</i>) is precisely expressed in ...[more]