Cue-elicited craving, thalamic activity, and physiological arousal in adult non-dependent drinkers.

ABSTRACT: Changes in physiological arousal frequently accompany cognitive and affective challenges. Many studies employed cue exposure paradigms to investigate the neural processes underlying cue-elicited drug and alcohol craving. However, whether cue-elicited craving relates to changes in physiological arousal and the neural bases underlying the potential relationship remain unclear. Here we examined cerebral cue-related activations in relation to differences in skin conductance responses (SCR) recorded during alcohol vs. neutral cue blocks in 61 non-dependent alcohol drinkers (30 men). Imaging and skin conductance data were collected and processed with published routines. Mediation analyses were conducted to examine the inter-relationship between regional activities, cue-elicited craving, and SCR.

SUBMITTER: Wang W 

PROVIDER: S-EPMC6606341 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature