Independent markers of nonalcoholic fatty liver disease in a gentrifying population-based Chinese cohort.

ABSTRACT:

Background

Prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in developing countries, but its causes are not known. We aimed to ascertain the prevalence and determinants of NAFLD in a new largely unmedicated population-based cohort from the rapidly gentrifying region of Pinggu, China.

Methods

We randomized cluster sampled 4002 Pinggu residents aged 26 to 76 years. Data from 1238 men and 1928 women without significant alcohol drinking or hepatitis virus B or C infection were analysed. NAFLD was defined using a liver-spleen ratio (L/S ratio) ≤1.1 on unenhanced abdominal computed tomography (CT) scanning.

Results

Of men and women, 26.5% and 20.1%, respectively, had NAFLD. NAFLD prevalence was highest in younger men and older women. In multivariate logi

SUBMITTER: Zhou X 

PROVIDER: S-EPMC6606362 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature