Ontology highlight
ABSTRACT:
SUBMITTER: Gaublomme JT
PROVIDER: S-EPMC6606589 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nature communications 20190702 1
Single-nucleus RNA-seq (snRNA-seq) enables the interrogation of cellular states in complex tissues that are challenging to dissociate or are frozen, and opens the way to human genetics studies, clinical trials, and precise cell atlases of large organs. However, such applications are currently limited by batch effects, processing, and costs. Here, we present an approach for multiplexing snRNA-seq, using sample-barcoded antibodies to uniquely label nuclei from distinct samples. Comparing human bra ...[more]