Evaluation of microneedles-assisted in situ depot forming poloxamer gels for sustained transdermal drug delivery.

ABSTRACT: In this study, for the first time, we have reported a sustained transdermal drug delivery from thermoresponsive poloxamer depots formed within the skin micropores following microneedle (MN) application. Firstly, we have investigated the sol-gel phase transition characteristics of poloxamers (PF®127, P108, and P87) at physiological conditions. Rheological measurements were evaluated to confirm the critical gelation temperature (CGT) of the poloxamer formulations with or without fluorescein sodium (FS), as a model drug, at various concentrations. Optimized poloxamer formulations were subjected to in vitro release studies using a vial method. Secondly, polymeric MNs were fabricated using laser-engineered silicone micromolds from various biocompatible polymeric blends of Gantrez S-97, PEG 1000

SUBMITTER: Khan S 

PROVIDER: S-EPMC6606675 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature