Gut microbiota in Parkinson's disease: Temporal stability and relations to disease progression.

ABSTRACT:

Background

Several publications have described differences in cross-sectional comparisons of gut microbiota between patients with Parkinson's disease and control subjects, with considerable variability of the reported differentially abundant taxa. The temporal stability of such microbiota alterations and their relationship to disease progression have not been previously studied with a high-throughput sequencing based approach.

Methods

We collected clinical data and stool samples from 64 Parkinson's patients and 64 control subjects twice, on average 2·25 years apart. Disease progression was evaluated based on changes in Unified Parkinson's Disease Rating Scale and Levodopa Equivalent Dose, and microbiota were characterized with 16S rRNA gene amplicon sequencing.

Findings</

SUBMITTER: Aho VTE 

PROVIDER: S-EPMC6606744 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature