PiRDisease v1.0: a manually curated database for piRNA associated diseases.

ABSTRACT: In recent years, researches focusing on PIWI-interacting RNAs (piRNAs) have increased rapidly. It has been revealed that piRNAs have strong association with a wide range of diseases; thus, it becomes very important to understand piRNAs' role(s) in disease diagnosis, prognosis and assessment of treatment response. We searched more than 2500 articles using keywords, such as `PIWI-interacting RNAs' and `piRNAs', and further scrutinized the articles to collect piRNAs-disease association data. These data are highly complex and heterogeneous due to various types of piRNA idnetifiers (IDs) and different reference genome versions. We put considerable efforts into removing redundancy and anomalies and thus homogenized the data. Finally, we developed the piRDisease database, which incorporates exper

SUBMITTER: Muhammad A 

PROVIDER: S-EPMC6606758 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature