Increased error-free DNA repair gene expression through reprogramming in human iPS cells.

ABSTRACT:

Introduction

Many studies have reported that human-induced pluripotent stem (hiPS)/embryonic stem (hES) cells have an exceptional ability to repair damaged DNA. Moreover, unlike differentiated cells, hES cells have features and mechanisms such as apoptosis-prone mitochondria, which prevent any changes in genetic information caused by DNA damage to be transmitted to their descendants. Type-A (dark) spermatogonia and cancer stem cells are thought to be dormant. However, hiPS/hES cells, the so-called stem cells used in regenerative medicine, generally have a high proliferative capacity. This suggests that in these cells, oxidative DNA damage associated with vigorous proliferation and DNA scission associated with replication occur frequently. Although pluripotency according to change o

SUBMITTER: Yoshimura Y 

PROVIDER: S-EPMC6606834 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature