PoFUT1 promotes endometrial decidualization by enhancing the O-fucosylation of Notch1.

ABSTRACT:

Background

Endometrial stromal cell decidualization is critical for embryo implantation. Dysfunctional decidualization leads to implantation failure, miscarriage and even pregnancy associated disorders in subsequent pregnancy trimesters. Protein glycosylation is involved in many physiological and pathological processes. Protein O-fucosyltransferase 1 (poFUT1) is the key enzyme for the O-fucosylation of proteins. However, the role and mechanism of poFUT1 in human endometrial stromal cell decidualization remain elusive.

Methods

We employed immunohistochemistry to detect the level of poFUT1 in the uterine endometrium from those of the proliferative phase, secretory phase, early pregnancy women and miscarriage patients. Using human endometrial stromal cells (hESCs) and a mouse m

SUBMITTER: Yang Y 

PROVIDER: S-EPMC6606927 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature