Salivary Gland Stem Cells Age Prematurely in Primary Sjogren's Syndrome.

ABSTRACT:

Objective

A major characteristic of the autoimmune disease primary Sjögren's syndrome (SS) is salivary gland (SG) hypofunction. The inability of resident SG stem cells (SGSCs) to maintain homeostasis and saliva production has never been explained and limits our comprehension of mechanisms underlying primary SS. The present study was undertaken to investigate the role of salivary gland stem cells in hyposalivation in primary SS.

Methods

SGSCs were isolated from parotid biopsy samples from controls and patients classified as having primary SS or incomplete primary SS, according to the American College of Rheumatology/European League Against Rheumatism criteria. Self-renewal and differentiation assays were used to determine SGSC regenerative potential, RNA was extracted for seq

SUBMITTER: Pringle S 

PROVIDER: S-EPMC6607019 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature