Comprehensive Uncertainty Quantification and Sensitivity Analysis for Cardiac Action Potential Models.

ABSTRACT: Recent efforts to ensure the reliability of computational model-based predictions in healthcare, such as the ASME V&V40 Standard, emphasize the importance of uncertainty quantification (UQ) and sensitivity analysis (SA) when evaluating computational models. UQ involves empirically determining the uncertainty in model inputs-typically resulting from natural variability or measurement error-and then calculating the resultant uncertainty in model outputs. SA involves calculating how uncertainty in model outputs can be apportioned to input uncertainty. Rigorous comprehensive UQ/SA provides confidence that model-based decisions are robust to underlying uncertainties. However, comprehensive UQ/SA is not currently feasible for whole heart models, due to numerous factors including model complexity

SUBMITTER: Pathmanathan P 

PROVIDER: S-EPMC6607060 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature