Different Effects of His-Au NCs and MES-Au NCs on the Propagation of Pseudorabies Virus.

ABSTRACT: In a previous work, gold nanoclusters (Au NCs) are found to inactivate RNA virus, but the effect of surface modification of Au NCs on its proliferation is still largely unknown. Here, the effect of surface modification of Au NCs on the proliferation of pseudorabies virus (PRV) by synthesizing two types of gold clusters with different surface modification, histidine stabilized Au NCs (His-Au NCs) and mercaptoethane sulfonate and histidine stabilized Au NCs (MES-Au NCs), is investigated. His-Au NCs rather than MES-Au NCs could strongly inhibit the proliferation of PRV, as indicated by the results of plaque assay, confocal microscopic analysis, Western blot assay, and quantitative real-time polymerase chain reaction (PCR) assay. Further study reveals that His-Au NCs perform the function via b

SUBMITTER: Feng C 

PROVIDER: S-EPMC6607262 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature