Identification of a miRNA-mRNA network associated with lymph node metastasis in colorectal cancer.

ABSTRACT: Lymph node metastasis is an important step in the progression of colorectal cancer (CRC); however, the underlying mechanisms are still unknown. The aim of the present study was to identify the gene expression pattern during lymph node metastasis in CRC and to identify upstream microRNAs (miRNAs) to explore the underlying mechanisms in detail. A total of 305 differently expressed genes (DEGs) were identified, including 227 upregulated genes and 78 downregulated genes in lymph node metastasis. Pathway and process enrichment analysis demonstrated that DEGs were significantly enriched in 'NABA CORE MATRISOME', 'extracellular matrix assembly', 'antimicrobial humoral response' and 'Toll-like receptor signaling' pathways. The top 10 hub genes were identified by protein-protein interaction network

SUBMITTER: Ju Q 

PROVIDER: S-EPMC6607389 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature