Enantioselective Coupling of Dienes and Phosphine Oxides.

ABSTRACT: We report a Pd-catalyzed intermolecular hydrophosphinylation of 1,3-dienes to afford chiral allylic phosphine oxides. Commodity dienes and air stable phosphine oxides couple to generate organophosphorus building blocks with high enantio- and regiocontrol. This method constitutes the first asymmetric hydrophosphinylation of dienes.

SUBMITTER: Nie SZ 

PROVIDER: S-EPMC6607437 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature