Identification of key genes involved in myocardial infarction.

ABSTRACT:

Background

This study focuses on the identification of conserved genes involved in myocardial infarction (MI), and then analyzed the differentially expressed genes (DEGs) between the incident and recurrent events to identify MI-recurrent biomarkers.

Methods

Gene expression data of MI peripheral blood were downloaded from GSE97320 and GSE66360 datasets. We identified the common DEGs in these two datasets by functional enrichment analysis and protein-protein interaction (PPI) network analysis. GSE48060 was further analyzed to validate the conserved genes in MI and to compare the DEGs between the incident and recurrent MI.

Results

A total of 477 conserved genes were identified in the comparison between MI and control. Protein-protein interaction (PPI) network showed hub

SUBMITTER: Qiu L 

PROVIDER: S-EPMC6607516 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature