Effect of disease-modifying anti-rheumatic drugs on bone structure and strength in psoriatic arthritis patients.

ABSTRACT: OBJECTIVES:To address whether the use of methotrexate (MTX) and biological disease-modifying anti-rheumatic drugs (bDMARDs) impacts bone structure and biomechanical properties in patients with psoriatic arthritis (PsA). METHODS:This is a cross-sectional study in PsA patients receiving no DMARDs, MTX, or bDMARDs. Volumetric bone mineral densities (vBMDs), microstructural parameters, and biomechanical properties (stiffness/failure load) were determined by high-resolution peripheral quantitative CT and micro-finite element analysis in the respective groups. Bone parameters were compared between PsA patients with no DMARDs and those receiving any DMARDs, MTX, or bDMARDs, respectively. RESULTS:One hundred sixty-five PsA patients were analyzed, 79 received no DMARDs, 86 received DMARDs, of them

SUBMITTER: Simon D 

PROVIDER: S-EPMC6607518 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature