Redox/NIR dual-responsive MoS₂ for synergetic chemo-photothermal therapy of cancer.

ABSTRACT:

Background

The construction of a multifunctional drug delivery system with a variety of advantageous features, including targeted delivery, controlled release and combined therapy, is highly attractive but remains a challenge.

Results

In this study, we developed a MoS₂-based hyaluronic acid (HA)-functionalized nanoplatform capable of achieving targeted delivery of camptothecin (CPT) and dual-stimuli-responsive drug release. HA was connected to MoS₂ via a disulfide linkage, forming a sheddable HA shell on the surface of MoS₂. This unique design not only effectively prevented the encapsulated CPT from randomly leaking during blood circulation but also significantly accelerated the drug release in response to tumor-associated glutathione (GSH).

SUBMITTER: Liu J 

PROVIDER: S-EPMC6607525 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature